الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Insulin has been well known for the treatment of type I diabetes mellitus, however; it had many non-diabetic uses; one of which is the wound healing. Several studies proved the efficacy of Insulin in wound healing probably due to several reasons as increasing the nitrogen retention related to the amino acid uptake and hence catabolism, by helping to promote glucose utilization in the tissues, normalizing permeability, increasing vascularization, reducing exudate, arresting bacterial growth, enhancing phagocytosis, stimulating proliferation, reducing tissue hypoxia, eliminating edema and increasing wound contracture. Although theoretically, it is an excellent wound healing agent, it suffers major problems; firstly, is the stability either during the application at the wound area due to the presence of the proteases enzyme, or storage stability being a protein thus; susceptible to denaturation by any means. Moreover; it lacks a vehicle that transports it reliably in a controllable manner, to guard against all of the above problems