الفهرس 
Potential role of neutrophil-platelet interaction in increased susceptibility of downs syndrome patients to infection
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Abstract
Down syndrome (DS) is the most common chromosomal aneuploidy in live births. DS is associated with some degree of cognitive impairment, in addition to an increased chance of developing a variety of other medical and surgical conditions, the majority of which are treatable, many immunologic disorders have been defined in patients with DS, The rise in the prevalence of both infections and autoimmune disorders are thought to be related to immune disorders, Genome-wide expression analysis in DS showed that Leukocyte trans-endothelial migration pathway which is vital for immune surveillance and inflammation is dysregulated; Endothelial transmigration of neutrophils is elicited by binding of PSGL-1 or CD11b/CD18 (MAC-1) to platelet CD62P and is further enhanced by binding of CD40 to platelet derived soluble CD40 ligand (sCD40L). Our study included 34 DS patients, a control group of 39 healthy age matched volunteers were also involve, All patients were subjected to full history taking including family history and thorough clinical examination, laboratory investigations, the main presenting clinical features were slanted eyes and hypotonia; CBC, Conventional karyotyping (all patients were trisomy 21) and flowcytometry for platelet CD 40, CD18 and neutrophil CD 62p were done to all patients