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Abstract Background: Patient safety is the foundation of good patient care and the avoidance and prevention of patient injuries or adverse events resulting from the processes of health care delivery. Aim of the study: To assess the nurses{u2019} adherence to the national standards of patient safety. Design: A descriptive design was used to achieve the aim of the current study. Sample: Convenient samples of 48 nurses were participated in the current study. Setting: The current study was conducted at all surgical units in Port Said governorate hospitals. Tool: data was collected by using the patient safety standards observation check list. Results:The study{u2019}s results revealed that, nurses in the study mostly adhere to the standards of Eliminating Wrong-Site, Wrong-Patient, Wrong- Surgical Procedure and improving effective communication among health care workers. There was statistically significance correlation between nurses{u2019} adherence to national standards of patient safety and workload during some shifts and there was no correlation between nurses{u2019} adherence to national standards of patient safety and their average age during some shifts |