الفهرس 
Title: The relation of glucagone like peptide-1 and saffron to advanced glycation end products (AGEs) in management of induced diabetic nephropathy in rats
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Abstract
Diabetes mellitus (DM) is the most prevalent metabolic disorder. The prevalence of DM is nearly 6% of the population and type II DM constitutes 90 to 95% of it. Diabetic nephropathy (DN) is one of the devastating complications in patients with DM. Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in DN. Glucagon-like peptide-1 (GLP-1) is one of the incretins secreted from L cells in the intestine in response to food intake. It is claimed that, GLP-1 inhibits the AGE-induced inflammatory reactions in endothelial cells. Saffron is the dried stigmata of the flowers of saffron. Crocin (the active ingredient of saffron) could inhibit adhesion of leukocytes to the endothelial cells induced by AGEs possibly through its antioxidant activity. We investigated the renal protective effect of GLP-1 agonist and crocin in DN. Thirty male albino rats were divided randomly into the following 5 groups; control, type II diabetic rats, type II diabetic rats treated with GLP-1 analogue, type II diabetic rats treated with Crocin and type II diabetic rats treated with combined GLP-1 and Crocin