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العنوان
Application of some nanoparticles for the oral delivery of a biopharmaceutics classification system (BCS) class II drug /
الناشر
Nihal Mohamed Elmahdy Elsayyad ,
المؤلف
Nihal Mohamed Elmahdy Elsayyad
هيئة الاعداد
باحث / Nihal Mohamed Elmahdy Elsayyad
مشرف / Alia A. Badawi
مشرف / Hanan M. El-Laithy
مشرف / Nevine S. Abdel Malak
مناقش / Samia Nour
تاريخ النشر
2018
عدد الصفحات
216 Leaves :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
16/6/2018
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Industrial Pharmacy
الفهرس
Only 14 pages are availabe for public view

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from 260

Abstract

The main goal of this work is to employ nanoparticles technology in the form of cubosomes to enhance the oral bioavailability of BCS class II drug, clopidogrel bisulphate (CB) by enhancing its solubility in intestinal pH, which is its main site of absorption and its formulation into convenient, stable dosage form suitable for patient use. CB is a thienopyridene class anti-platelet oral drug. It is indicated for the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease