الفهرس 
Title : Comparative study of the efficacy and safety of di-peptidyl peptidase inhibitors versus metformin in diabetic hypertensive patients
AbstractOnly 14 pages are availabe for public view
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Abstract
Background: Several trials have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors, used to improve endothelial function in addition to treating type 2 diabetes. The current study investigated the effects of vildagliptin, DPP-4 inhibitor, compared to metformin on endothelial function, and blood pressure through vascular endothelial growth factor (VEGF) modulation in patients with T2DM and hypertension. Methods: This study was designed as a randomized controlled parallel study. A total of 120 volunteers were recruited and allocated into four groups: healthy volunteers,patients recently diagnosed with hypertension and diabetes, patients treated with captopril for hypertension in addition to metformin, and patients treated with captopril in addition to vildagliptin.The percent change in body weight was calculated in addition to serum VEGF levels, blood pressure, glycated haemoglobin (HbA1c), total lipid profile and insulin resistance. Results: At the end of the therapeutic period, the results showed that vildagliptin significantly decreased blood pressure and increased serum VEGF levels, while metformin was more effective at lowering body weight. In comparison with metformin, vildagliptin showed a promising action through its antihypertensive effect via elevating VEGF levels and improving physiological angiogenesis and vasculature