الفهرس 
A pharmaceutical study on certain antihypertensive drugs in multilayer tablets
Abstract EnglishOnly 14 pages are availabe for public view
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Abstract
The aim of this work is to prepare and evaluate core in cup mucoadhesive controlled release tablet of Azelnidipine (AZL), aiming to control its release, to reduce ’see-saw’ fluctuation and maintain a steady drug concentration in blood circulation. Also to prepare core in cup mucoadhesive immediate release tablet of Olmesartan (OLM), aiming to increase its bioavailability. Also, the target is to prepare combined core in cup mucoadhesive AZL/OLM tablet, aiming to give powerful blood pressure-reducing effects. Thus the work in this thesis is divided into three chapters: Chapter I: Formulation and evaluation of core in cup mucoadhesive controlled release AZL tablet. Chapter II: Formulation and evaluation of core in cup mucoadhesive immediate release OLM tablet and the combined core in cup mucoadhesive AZL/OLM tablet. Chapter III: In-vivo performance of the optimized combined core in cup mucoadhesive AZL/OLM tablet. It was concluded that the newly formulated combined core in cup mucoadhesive AZL/OLM tablets exhibits several advantages over the oral marketed 2Rezaltas® 10/8 mg tablets3, which are, allowing faster more efficient clinical effect in case of OLM, higher rate and extent of drug absorption due to the avoidance of AZL first-pass hepatic metabolism by the buccal route, needs not to be swallowed, it could be a good alternative for geriatric patients, causing an increase in safety beside the pharamcoeconomeic advantage