الفهرس 
Impact of Silver Nanoparticles and Sodium-Butyrate in Impedance of Colisepticemia in Broiler Chickens
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Abstract
The present trial conducted to evaluate the efficacy of usage of silver nanoparticles (Ag-NPs) and sodium butyrate (Na-B) encapsulated in palm fat as antimicrobial alternatives. Therefore, the inhibitory effect of Ag-NPs against E.coli was determined in vitro. Then, the effects of its use (in different doses) and sodium butyrate on experimentally induced colisepticaemic broiler chickens for a period of 35 days were studied in vivo through measuring the clinicopathological assay (daily) and performance variables (weekly) in addition to some measurements at the end of experiment like gross lesions scoring; related organ weight; E. coli re-isolation; E. coli virulence gene expression by rt-qPCR; morphological characterization of E.coli using (TEM) and histopathological examination. In vitro study was carried out by Disk diffusion method by using pure form of Ag-NPs (2000 ppm) and other concentrations (200, 20, 2, 10, 5, 2.5 and 0 ppm). then, in vivo study was done using one day-old Cobb chickens (n = 180) allotted randomly into 6 equal groups (1-6). Each group consisted of 30 birds with 3 replicates of 10 each