الفهرس 
Bioavailability enhancement of a certain antiplatelet drug via the use
Table of ContentsOnly 14 pages are availabe for public view
 |  | from | 236 |  |  |
| | | from | 236 | | |
Abstract
The aim of this thesis is to formulate and evaluate Clopidogrel (CLP) loaded-SNEDDS, CLP loaded-solid SNEDDS and CLP cubosomal dispersion to enhance its oral bioavailability. CLP is an oral antiplatelet drug belonging to thienopyridine class, it is an important therapeutic agent for patients who are at risk for cardiovascular events like myocardial infarction, peripheral vascular disease, and stroke. It is a prodrug, suffers from hepatic first pass metabolism which leads to its poor oral bioavailability. CLP loaded-SNEDDS were prepared based on pseudo-ternary phase diagrams. Different oils, surfactants and co-surfactants were tested regarding CLP solubility to choose the best isotropic mixture. Accordingly, two systems were selected; system I composed of Capryol{u2122}90: Tween®80: PEG400, while system II composed of Capryol{u2122}90: Cremophore®EL: Transcutol®HP. Drug-loaded systems were characterized regarding robustness to dilution, visual inspection, % transmittance, viscosity measurements and in-vitro release study. Best formula that significantly had lower nanosize and highest percentage drug release was successfully adsorbed onto a solid carrier namely Aeroperl®Pharma with a ratio 1: 0.75 (w/w) as solidification mean to increase its chemical and physical stability. S-SNEDDS formula was characterized by differential scanning calorimetry, Fourier transform infrared (FTIR) and scanning electron microscopy. Furthermore, the optimum solid formula packed in hard gelatine capsule and used for the in-vivo investigation study