الفهرس 
Synthesis of some novel pyridine derivatives bearing a sulfonamide moiety
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Abstract
In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action