الفهرس 
The efficacy and safety of intrauterine misoprostol versus rectal misoprostol in reducing blood loss during and after cesarean section
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Abstract
Objective: To compare the efficacy and safety of preoperative rectal misoprostol versus intraoperative intrauterine misoprostol in the reduction of blood loss during and after lower segment caesarean delivery. Methodology: 98 pregnant women, candidate for LSCS, were equally randomized into 2 groups: rectal misoprostol group (received 400 microgram misoprostol rectally preoperatively) and intrauterine misoprostol group (received 400 microgram misoprostol inserted intrauterine intraoperatively following the delivery of the placenta). The 1ry outcome was the estimated blood loss (EBL) during cesarean delivery and 2ry outcomes included the occurrence of excessive blood loss (> 1000 mL) within the first 24 hours postoperatively and the occurrence of any maternal or fetal side effects. Results: no statistically significant difference between the two studied groups regarding the estimated blood loss. Furthermore, there was no statistically significant difference between them as regard the occurrence of postpartum hemorrhage (> 1000ml in the first 24 hours) and the Apgar score of the neonate at 1 minute. Only Apgar score at 5 min was significantly higher in intrauterine group compared to rectal group.Conclusion: the intrauterine misoprostol insertion is equally effective and safer than the rectal misoprostol insertion in the reduction of blood loss during and after lower segment caesarean delivery