الفهرس 
Speckle tracking echocardiography and serum nitrous oxide levels for assessment of the role of vascular dysfunction in induction of myocardial dysfunction in sickle cell disease patients in Cairo University Children Hospital
AbstractOnly 14 pages are availabe for public view
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Abstract
Back ground: SCD is a chronic inflammatory state with extensive oxidative stress involving several enzyme systems and ischemia /reperfusion injury, with nitric oxide (NO) dysregulation playing a central role. Another model of SCD pathophysiology has therefore been proposed that involves the interaction of hemolysis and the endothelium (Hagar et al., 2008). Cardiac complications are a common, often unrecognized, cause of morbidity and mortality in SCD, and are a major cause of death in adult patients (Voskaridou et al., 2007). Cardiovascular complications are increasingly evident, with the notable development of a progressive proliferative systemic vasculopathy, pulmonary hypertension (PH), and left ventricular diastolic dysfunction.Chronic anemia in SCD results in cardiac chamber dilation and a compensatory increase in left ventricular mass. This is often accompanied by left ventricular diastolic dysfunction that has also been a strong independent predictor of mortality in patients with SCD (Hagar et al., 2008). Objectives: The aim of study is early detection of subtle myocardial dysfunction in SCD patients and to examine the potential deficiency of circulating nitric oxide as sign of endothelial dysfunction