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العنوان
Effect of curcumin on brain injury induced by intestinal ischemia-reperfusion in mice /
الناشر
Noha Farid Elshazly ,
المؤلف
Noha Farid Elshazly
هيئة الاعداد
باحث / Noha Farid Elshazly
مشرف / Samira Saleh Mostafa
مشرف / Azza Sayed M. Awad
مشرف / Nesrine Salah Eldin
تاريخ النشر
2019
عدد الصفحات
126 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
25/9/2019
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmacology and Toxicology
الفهرس
Only 14 pages are availabe for public view

from 140

from 140

Abstract

Intestinal ischemia/reperfusion (II/R) induces a systemic inflammatory response and releases harmful substances that may affect the function and integrity of distant organs such as brain, lung, liver, and kidney. Oxidative stress and inflammatory cytokines are among the key mechanisms of brain tissue damage after intestinal ischemia reperfusion. Therefore improving the redox balance, abating the inflammatory cytokines are the most important goals to attenuate damage after intestinal ischemia reperfusion. Curcumin (CUR), the turmeric is the common name for Curcuma longa, exhibit several pharmacologic properties as anti-inflammatory and antioxidant agent and exert neuroprotective effects in a variety of neurodegenerative disorders including Alzheimer{u2019}s disease, Parkinson{u2019}s disease, and cerebral ischemia by crossing the blood{u2013}brain barrier Moreover, Curcumin is known to play a vital role against oxidative-stress-mediated pathological conditions. , protect biomembranes against peroxidative damage