الفهرس 
Title : Active vs inactive vitamin D in treatment of vitamin D deficiency / insufficiency in children with chronic kidney disease
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Abstract
Background: CKD leads to a vitamin D deficiency despite a progressive risein serum PTH concentrations. Reduced functional renal mass, phosphate retention, and other metabolites that accumulate in kidney failure contribute to 1-alpha hydroxylase inhibition and Vitamin D deficiency in CKD. There are two different modalities in treating vitamin D deficiency in CKD children with active or inactive forms of vitamin D. Methods: In a cross over observational study, 30 CKD patients with vitamin D deficiency were randomly classified into 2 groups, group A received inactive vitamin D while group B received active vitamin D for three months, then group A patients received active vitamin D while group B received inactive vitamin D for another three months. Serum Ca, Po4, ALP, serum 25(OH)D and PTH were measured at baseline level then after treatment with each form. Results: After treatment with inactive vitamin D there is significant increase in serum 25(OH)D level (P > 0.0001) in group A children and significant increase (P= 0.0001) in group B children. After treatment with active vitamin D there is significant increase in 25(OH)D level P > 0.0001) in group A children, and significant increase (P=0.0018) in group B children. with no statistically significant difference between active and inactive forms of vitamin D. Conclusion: There is significant increase in serum 25(OH)D level after treatment with active and inactive vitamin D with no statistically significant difference between both forms