الفهرس 
Title : Effect of some agents on testicular functions in a rat model of chronic mild stress-induced depression
contentsOnly 14 pages are availabe for public view
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Abstract
Chronic stress occurs in everyday life and may lead to depression. chronic stress is a major factor contributing to male infertility. Increasing evidence has demonstrated that resveratrol or dimethyl fumarate (DMF) has antioxidant and anti-inflammatory functions. The present study was designed to explore the possible protective effects of resveratrol or DMF against the testicular dysfunction associated with depressive brain in a rat model of chronic unpredictable mild stress (CUMS). Rats were subjected to 8 weeks of CUMS to induce depressive-like symptoms. CUMS-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal BDNF levels. CUMS significantly reduced sucrose preference and increased immobility time in stressed rats. CUMS exposure significantly decreased and increased expression levels of Ý-catenin and GSK-3Ý, respectively in the hippocampus and testes. Furthermore, CUMS exposure resulted in a significant increase in hippocampal and testicular expression levels of NF-mB, TNF-Ü and IL-1Ý and a significant decrease in Bcl-2 expression levels as well as a significant increase in testicular expression levels of Bax. CUMS caused a significant increase and decrease in levels of MDA and GSH, respectively in the hippocampus and testes as well as a significant decrease in serum total antioxidant capacity levels compared to the control group