الفهرس 
Title : Neonatal urinary uric acid/creatinine ratio as an additional marker of perinatal asphyxia
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Abstract
Background :Perinatal hypoxia is one of the leading causes of perinatal mortality in developing countries. Both Apgar score and arterial blood pH predict the neonatal mortality in asphyxia. Apgar score alone does not predict neurologic outcome and as it is influenced by various factors. This study was conducted to evaluate the utility and sensitivity of urinary uric acid to creatinine ratio (UA/Cr ratio) in asphyxia diagnosis, compared to invasive Arterial Blood Gas (ABG) analysis. Aim: To assess the urinary uric acid/creatinine ratio as an additional marker for perinatal asphyxia compared with ABG analysis in Apgar score monitoring. Materials and Methods: The present case control study was conducted at kasr Al-Aani teaching hospital . Data of 40 healthy newborns and 40 asphyxiated newborns were collected. (UA/Cr) ratio was measured from the spot urine sample collected during 24-72 hours of birth Results : The mean (UA/Cr ratio) (3630.29 vs 234.80) is significantly higher in asphyxiated group than in the control group (p<0.0001). Urinary UA/Cr ratio had positive correlation with blood pH (r :0.649 ) (p<0.0001),PCO2(r: 0.471) (p 0.002),HCO3 (r:0.632) (p<0.0001) , oxygen saturation (r0.668) (p<0.0001), Apgar at 1 minute (r:0.054) (p<0.0001) , Apgar at 5 minutes (r:0.105) and Apgar at 10 minutes (r :0.087) (p<0.0001)UA/Cr had 100% sensitivity, 100% specificity and a positive predictive value of 100%