الفهرس 
Title : Prognostic value of microRNA-21/ Ki-67 in non-hodgkin`s lymphoma, Egypt
CONTENTSOnly 14 pages are availabe for public view
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Abstract
MicroRNA-21 (MIR-21) is a small non-coding RNA that inhibits target genes expression thus affects tumorigenesis. Ki 67 is a nucleolar protein antigen in proliferating cells. Ki 67 expression is highly correlated with the proliferation rate. Immunohistochemical assay (IHC) of Ki67 antigen in paraffin section (Ki67 proliferative index) represents the active growth fraction of the tumor. We aim to evaluate the diagnostic and prognostic value of MIR-21 and Ki 67 as a potential biomarker of non- Hodgkin`s lymphoma (NHL) Methods: We prospectively enrolled 64 newly diagnosed B-NHL (DLBCL) patients (from May 2017 to 2018). Serum MIR-21 and tissue Ki 67 were assessed with RT- PCR and IHC of lymph node biopsy respectively. The primary outcomes were to identify overall survival (OS), and progression free survival (PFS), while the secondary outcomes were to identify the associations between different variables and MIR-21 and Ki 67. Spearman{u2019}s correlation was used and expressed as correlation coefficient (r). Kaplan-Meier survival curves were used and compared using log-rank. Cox regression was used to identify the independent predictors of survival