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العنوان
Performance characteristics of ion selective electrodes for potentiometric determination of some pharmaceutical compounds /
الناشر
Alaa Abdouallah Ali Mohamed ,
المؤلف
Alaa Abdouallah Ali Mohamed
هيئة الاعداد
باحث / Alaa Abdouallah Ali Mohamed
مشرف / Sally Elsayed Ahmed
مشرف / Gehad Genidy Mohamed
مناقش / Sally Elsayed Ahmed
تاريخ النشر
2019
عدد الصفحات
144 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Analytical Chemistry
تاريخ الإجازة
15/12/2019
مكان الإجازة
جامعة القاهرة - كلية العلوم - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

from 190

from 190

Abstract

In this work, modified carbon paste electrodes (MCPEs) were used to determine alfuzosin hydrochloride (ALFHC) in pure, pharmaceutical preparation and biological fluid samples. Different MCPEs modified with different ion pairs as ALF-PTA, ALF-TPB, ALF-PMA and ALF-RN were prepared. The second part of this work is to determine vilazodone hydrochloride drug by the potentiometric calibration method. Several screen printed electrodes (SPEs) were prepared and modified with different ion pairing agents as NaTPB, RN, PTA and PMA. The proposed electrodes gave the Nernstian slope and showed good selectivity to VILA with respect to the interfering species. The electrodes were characterized and investigated with respect to the experimental parameters affecting their performance including plasticizers, pH, interference and life time. The electrodes showed good selectivity to the drugs under study with respect to the interfering species. Then, validation parameters were achieved. The obtained results were in a good agreement with those obtained by the reported method