الفهرس 
Title: Design, synthesis and biological evaluation of some quinazoline derivatives as phosphodiesterase 7 inhibitors
ContentsOnly 14 pages are availabe for public view
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Abstract
Recent studies showed the beneficial effect of inhibiting phosphodiesterase 7A enzyme on improving neurodegenerative diseases as well as neurotraumatic conditions. In addition, quinazoline derivatives are of considerable chemical and pharmacological importance as therapeutic agents. In this work, 18 novel 2-substituted quinazolin-4(3H)-one derivatives were synthesized in six series. The target compounds highlighted a variety of bioactive chemical fragments found in CNS active agents. Phosphodiesterase 7A inhibitory activity study was performed for all synthesized compounds as well as behavioral study for the most active compound. Furthermore, in silico studies were performed on the synthesized compounds which included molecular docking study at the active site of PDE 7A enzyme and prediction of their pharmacokinetic parameters