الفهرس 
Title : Study of the possible effects of certain drugs on aluminum-induced memory impairment in rats
ContentsOnly 14 pages are availabe for public view
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Abstract
Currently, there is no effective mean for treatment or prevention of Alzheimer{u2019}s disease (AD).Commonly used AD drugs have moderate effect and treat only the associated symptoms, therefore there is strong need to search for more effective agents. Our goal is to examine the neuroprotective effect of both telmisartan and cilostazol in aluminum-induced cognitive impairment in rats. Aluminum chloride (10 mg/kg, i.p) was administered for two months then behavioral tests (Y-maze and Morris water maze) were done. Hippocampal biochemical and histological analysis were then carried out. AD like histological, biochemical, and behavioral alterations appeared in aluminum treated rats. Both telmisartan and cilostazol improved rats condition on behavioral and histological levels. They reversed the increase in hippocampal amyloid beta protein, phosphorylated tau protein contents together with augmentation of neprilysin level, they also diminished levels of nuclear factor-kappaB, FAS ligand, tumor necrosis factor-alpha, malondialdehyde and acetylcholinesterase content These findings show the protective action of both telmisartan and cilostazol against AD-like pathological alterations