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Abstract This study was performed to evaluate the effect of gamma radiation on the microshear bond strength and nanoleakage in Er,Cr: YSGG laser prepared cavities as well as microhardness of two different restorative materials (Nanocomposite and Nano-glass ionomer) and enamel in two different storage periods (24 hrs and 6 months) Micro-shear bond strength test: Enamel was removed from all specimens to expose flat dentin surfaces then the flattened dentin surfaces were uniformly and perpendicularly irradiated with Er,Cr:YSGG laser.The prepared teeth were divided into two main groups according to the restorative material used. Two vinyl Tygon tubes were placed on each dentin surface where the restorative materials were packed.Each group was subdivided into two subgroups according to whether or not subjected to gamma radiation. Each subgroup was further divided into two classes according to the aging periods and stored in artificial saliva. Micro-shear bond strength assessment was performed by Instron universal testing machine |