الفهرس 
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Abstract
Summary and Conclusion
Non-alcoholic fatty liver disease comprises a disease spectrum associated with lipid deposition in liver. It could present as a simple steatosis or progress to more serious form of chronic liver disease. Its pathogenesis is complex; however, obesity is a primary risk factor for its development. High amount of abdominal fat can activate the lipocytic activity of adipocytes resulting in release of free fatty acids in portal venous system.
This can expose liver to considerable amount of fat leading to non-alcoholic fatty liver disease. The prevalence of non-alcoholic fatty liver disease is estimated to be 20–30%; however, it depends on the tool used in making diagnosis and the study population. Liver biopsy is the gold standard in the diagnosis of non-alcoholic fatty liver disease; however, various noninvasive imaging techniques are currently used in clinical practice.
Previous studies have demonstrated that visceral adipose tissue is clearly associated with non-alcoholic fatty liver disease. The current study aimed to evaluate the relationship between the severity of fatty liver in non-alcoholic fatty liver disease assessed by ultrasonography and computed tomography and the visceral fat area measured by computed tomography. Also, to investigate the relationships among the visceral fat area subcutaneous fat and liver enzymes.
The study enrolled 65 patients with non-alcoholic fatty liver disease based on abdominal computed tomography. Mean age of studied patients was 51.38 ± 11.11 years with range between 25 and 65 years. Out of the studied patients; 30 (46.2%) patients were males and 35 (53.8%) patients were females. Mean body mass index was 41.23 ± 7.83 (kg/m2). It was found that 25 (38.5%) patients were diabetics and 20 (30.8%) patients were hypertensive.
Based on radiological assessment of those patients; it was found that 30 (46.2%), 21 (32.3%) and 14 (21.5%) patients had grade-I, grade-II and grade III fatty liver, respectively. patients with grade-III fatty liver had significantly higher psoas muscle volume, total fat volume, visceral fat volume, subcutaneous fat volume, fat rate in the body and visceral fate volume rate in comparison to those with grade-I and those with grade-II fatty liver.
Also, it was found that liver enzymes had significant positive correlation with liver volume, psoas muscle volume, total fate volume and visceral fate volume rate. Based on the current study, it was found that there was increased subcutaneous as well as visceral fat deposition in patients with non-alcoholic fatty liver disease.
Also, amount of subcutaneous as well as visceral fat deposition in patients with non-alcoholic fatty liver disease was increasing with advancing in the disease grades. Multi centers future studies are warranted to confirm these findings.