الفهرس 
Myocardial InfarctionOnly 14 pages are availabe for public view
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Abstract
MI is characterized by an inequity of coronary blood supply and demand, which results in myocardial ischemic injury and damages the cardiomyocytes. several studies showed that during ischemic damage, oxidative stress produced by the generation of reactive oxygen species plays a key role in the development of MI. It is the most clinically encountered ischemic heart diseases and remains the foremost reason of death and disability worldwide (Prince and Hemalatha.,2018)
Vitamin E is a fat-soluble vitamin with antioxidant properties. It acts as a peroxyl radical scavenger, preventing the propagation of free radicals in tissues (Upaganlawar A et al.,2010)
PPIs are group of drugs that inhibit the activity of proton pumps transporting hydrogen ions across cell membranes. PPIs have antioxidant and anti-inflammatory functions in several cell types including immune, vascular endothelial and epithelial cells. The antioxidant property of the PPIs is reported to be due to direct scavenging of reactive oxygen species (ROS) (Ghebremariam et al.,2013)
This study was carried out on 40 adult male albino rats divided into 5 groups as follow: First group (group I) was the control group. Second group (group II) was injected with ISO. Third group (group III) was pantoprazole pretreated group 1.3mg/kg once daily for 3 weeks then injected by ISO on 22th and 23th day. Fourth group (group IV) was pretreated with vitamin E 100 mg/kg once daily for 3 weeks then injected by ISO on 22th and 23th day. Fifth group (group V) received both pantoprazole along with vitamin E for 3 weeks then injected by ISO on 22th and 23th day.
Parameters chosen to assess the protective effect of PPIs and Vitamin E supplementation on Heart function and oxidative stress included ECG recording, SBP and HR measurement in addition, serum levels of LDH, SOD, MDA and NO with histopathological examination of heart tissue.
The obtained results of this study could be summarized as follow: Induction of MI by ISO resulted in significant increases in ST segment height, T -wave voltage, HR, LDH, MDA and NO and associated with significant decreases in SBP and SOD levels when compared with the control group. Moreover, interventions with PPIs supplementation and / or vitamin E significantly reversed the aforementioned parameters with better impact of their combination.
from the above results we concluded that either PPIs or Vitamin E can exert a protective effect against MI induced by ISO with more beneficial effect of their combination.