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Abstract In the present study, we have evaluated the possible protective effects of GAL against hepatic and renal toxicity induced by PCM in rats. Forty adult male albino rats were used in the experiment. All rats divided into four groups each group contain 10 rats. The 1st group (control negative): Rats in this group were not medicated and left as control received physiological saline. The 2nd group (GAL): Rats in this group were received oral doses of GAL (0.3 mg/kg b.wt) daily by gavage for successive 28 days. The 3th group (PCM): Rats in this group were received a single oral administration of PCM (2 g/kg b.wt) by gavage at the day 29 of experiment. The 4th group (PCM + GAL): Rats in this group were received oral doses of GAL (0.3 mg/kg) daily by gavage for successive 28 days and PCM (2 g/kg b.wt) by gavage at the day 29 of experiment. The rats were anesthetized with ketamine/xylazine. After blood samples were collected from the vena cava, the blood was collected, permitted to coagulate, and then centrifuged at 3,000 rpm for 15 minutes. The serum samples were kept at -20 °C until they were needed. The kidney and liver tissues of rats were taken for histopathological analysis. |