الفهرس 
Sickle Cell DiseaseOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Sickle cell disease (SCD) is one of the most common genetic disorders, it not only has hematological pathophysiological consequences, but also has systemic pathological manifestations such as Sickle cell nephopathy(SN). There are no randomized control trials that examined the utility of screening test for renal disease in individuals with SCD.
Aim of the Work: The aim of this study is to evaluate urinary monocyte chemoattractant protein-1 (MCP-1) and urinary kidney injury molecule 1 (KIM-1) as biomarkers for early detection of sickle cell nephropathy and correlate them with proteinuria and decline in estimate glomerular filtration rate( eGFR)
Patient and Methods: This study was a Cross sectional study, conducted at Pediatrics Hematology-Oncology Unit at Ain Shams University Children’s Hospital, where 45 children with sickle cell disease were enrolled aged 6 months - 16 years. Urine samples were collected to measure MCP-1and KIM-1 levels and compared to age and sex matched control .
Results: There was a statistically significant difference found between control group and patients’ group regarding the level of MCP-1 in urine as it was found higher in patients than control group with (p<0.001)and regarding the level of KIIM-1 in urine as it was found higher in patients than control group with (p<0.001). .
Conclusion: Our data shows a distinct biomarker pattern in children with SCD, identifying KIM-1 and MCP-1 as two potential biomarkers of early SN and its progression.