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Abstract Breast cancer is a socially relevant group of malignant conditions of the mammary gland, affecting both males and females, showing a tendency for development after the third decade and increasing its incidence with age, peaking in the fourth and fifth decade. Worldwide it is the most commonly diagnosed malignant condition in females and one of the leading causes for metastatic disease and cancer-related deaths affecting women. Nearly 43% of women with breast cancer require mastectomy. Removal of the PF is still widely performed in the modified radical mastectomy and simple mastectomy. However, the necessity of this procedure is questionable. The PF is part of the muscular anatomy instead of the breast glandular tissue and, therefore, it seems theoretically of no oncological benefit to excise the PF except in those cases of tumor invasion in the PF. It is hypothesized that preservation of the PF has several advantages. It may reduce postoperative bleeding complications by preventing injury to the PM itself. Studies showed that 50% of postoperative bleeding requiring reoperation following mastectomy originated from the PM. Furthermore, PF preservation may decrease postoperative seroma formation due to its function in lymph drainage. The aim of the present study is to assess the oncological safety and the early complications on Pectoralis Fascia Preservation in Modified Radical Mastectomy. This is a randomized control trial, conducted at Operation rooms and in-patient ward of surgery in Suez Canal University Hospitals on patients divided into two groups: (group A); patients undergo preservation of |