الفهرس 
Systemic Lupus Erythematosus
7) Neuropsychiatric manifestations:Only 14 pages are availabe for public view
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Abstract
Background: Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue .RANTES (regulated on activation ,normal T-cell expressed and secreted ) a small protein is a member of the CC or B chemokine subfamily .It is involved in the pathophysiology of acute and chronic inflammatory processes of SLE by the recruitment of monocytes, T lymphocytes, and eosinophils to the sites of inflammation.Objectives: To assess the ability of RANTES to identify SLE, lupus nephritis and relation of this marker to lupus activity.Methods: This cross-sectional study was conducted on 90 subjects ; 60 patients with SLE and 30 healthy volunteers as a control .All subjects ( patients and control ) were subjected to full history taking and complete clinical examination ,routine investigations .Immunological assay and assessment of disease activity by systemic lupus erythematosus disease activity index (SLEDAI) score &renal SLEDAI (r-SLEDAI) were done for lupus nephritis groups.serum RANTES levels were measured by using ELISA for all groups.Results: The level of serum RANTES was significantly higher in SLE group than control group . .ROC curve analysis revealed that serum RANTES predicted presence of SLE with a sensitivity of 91.67% and a specificity of 86.67% .There was no significant difference in serum RANTES level between the active and inactive lupus patients or between lupus nephritis and non lupus nephritis groups . There was no significant correlation between serum RANTES and c3 , c4 , urinary proteins ,SLEDAI or r- SLEDAI scores.
Conclusion: Serum RANTES levels are increased in patients with Systemic lupus indicating that it can be a new useful biomarker for the diagnosis of systemic lupus disease with a sensitivity of 91.67% and a specificity of 86.67% .It has no relation to disease activity or presence of lupus nephritis .