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Abstract Abstract Weaning from mechanical ventilation is a serious and challenging process in critical care practice. Weaning failure is associated with poor patient outcomes. Increased mortality in patients with failed weaning was due to development of complications related to re-intubation. Detection and correction of the cause of failed spontaneous breathing trial (SBT) helps the intensives to improve the outcome of the next trials. Fluid overload and positive cumulative fluid balance is a risk factor of weaning failure. Weaning induced pulmonary edema (WIPE) has been reported in both cardiac and non-cardiac patients. Many tools for prediction of weaning induced cardiac edema have been reported. The gold standard for detection of WIPE was pulmonary artery catheter. More simple tools have been investigated for detection of WIPE in patients with or without previous cardiac dysfunction such as extravascular lung water, BNP (B-natriuretic peptide) levels, and biological signs of hemoconcentration |