الفهرس 
The relationship between CD14 CD16 blood monocytes with the severety of coronary artery disease in patients with acute coronary syndrome
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Abstract
Background: Acute coronary syndrome (ACS) is a disease of inflammatory aetiology, and remains the commonest cause of death globally despite therapeutic advances. Monocytes are implicated in the pathogenesis of coronary artery disease (CAD) and display a major role in the initiation, propagation, and progression of atherosclerosis. Aim: This study was designed to evaluate the relationship between monocyte subsets and the severity of ACS. Material and methods: This cross-sectional study was performed on all patients (40) with myocardial infarction who attended and sought medical advice in Kasr Elaini and (21) healthy subjects were enrolled. Clinical, laboratory and imaging assessments were done. Monocyte subsets analysis was performed using flow cytometry: CD14++CD16- (Monocyte1), CD14++CD16+ (Monocyte2), and CD14+CD16++ (Monocyte3). Results: We observed in our study increased total monocyte count in patients group compared with healthy subjects (P=0.04). Monocyte2 was positively correlated with patients who have severe stenosis (P=0.037), but Monocyte3 was negatively correlated (P=0.031) and number of vessels affected (p= 0.042), and no significant correlation was observed in Monocyte1. Concluson: The changes in different subsets of monocytes may be associated with pathogenesis of ACS and myocardial injury. A preferential increase in peripheral monocyte2 may be related to the severity of CAD in patients with ACS. The findings might be useful in the future therapeutic treatment of ACS