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العنوان
Some studies on camel nanobodies /
الناشر
Wafy Eid Hamed Farhan ,
المؤلف
Wafy Eid Hamed Farhan
هيئة الاعداد
باحث / Wafy Eid Hamed Farhan
مشرف / Rafik T. M. Soliman
مشرف / Khaled Farouk M. Elamry
مشرف / Nasser Abass Sherif
تاريخ النشر
2017
عدد الصفحات
86 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Veterinary (miscellaneous)
تاريخ الإجازة
18/3/2018
مكان الإجازة
جامعة القاهرة - كلية الطب البيطري - Microbiology
الفهرس
Only 14 pages are availabe for public view

from 103

from 103

Abstract

Camel antibodies is unusual simplified non canonical antibodies (HCAb) which devoid of CH1 domain and light chain which gave it great chance for different application in diagnosis and treatment. In this study, immunization of Egyptian camel with tetanus toxoid for studying the structure and features of camel nanobodies, the serum were collected and purified and found that the main antibody in serum of camel is HCAb (75-80kDa) which appeared by SDS-PAGE. The prophylactic and therapeutic effects of nanobodies were tested in groups of Mice injected with tetanus toxin. The camel antibodies can enter the nerve cell and neutralize the toxin and relieve the signs of toxicity