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Abstract
Stroke is a serious neurological disease, and constitutes a major cause of death and disability throughout the world. Stroke is defined by the WHO as the clinical syndrome of rapid onset (usually seconds or minutes) of focal (or global, as in subarachnoid hemorrhage) cerebral deficit, lasting more than 24 hours or leading to death, with no apparent cause other than a vascular one. Strokes can be classified into two major categories: ischemic and hemorrhagic. Ischemic strokes are those that are caused by interruption of the blood supply, while hemorrhagic strokes are the ones which result from rupture of a blood vessel or an abnormal vascular structure. About 87% of strokes are caused by ischemia and the remainder by hemorrhage. Disorders of thyroid gland may include: hyperthyroidism, hypothyroidism and euthyroid sick syndrome. Euthyroid sick syndrome can be described as abnormal findings on thyroid function tests that occur in the setting of a non thyroidal illness, without preexisting hypothalamic-pituitary and thyroid gland dysfunction. After recovery from a non thyroidal illness, these thyroid function test abnormalities should be completely reversible. Hyperthyroidism may cause ischemic stroke by its relation to AF. Hypothyroidism may cause ischemic stroke by it tendency to accelerate atherosclerosis. Objectives: This study was conducted to evaluate incidence of undiagnosed thyroid disorders in patients with acute ischemic stroke and their relation to age and sex, study effect of thyroid disorders on each of different risk factors and their effect on the outcome of those patients. Method: This is cross sectional study conducted on a cohort of 500 patients with acute ischemic stroke. All subjects of this study were subjected to the following: Full history and thorough physical examination. Lipid profile (LDL, total cholesterol, serum triglycerides), fasting plasma glucose level, thyroid profile (TSH, freeT3, freeT4).Other investigations included: ECG, Neuro-imaging: All patients were examined by CT scan at onset of admission to identify the vascular lesion and to determine the location site of lesion