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Abstract
Idiopathic pulmonary fibrosis (IPF), the most common idiopathic interstitial pneumonia (IIP), is characterized by progressive scarring of the lung parenchyma. The prognosis of IPF is poor, with a median survival from time of diagnosis of 3 years. The aim of the work: is to demonstrate the association between MUC5B promoter polymorphism and IPF that was observed to show strong association with IPF in many populations and to show if this association is present in Egyptian patients with idiopathic pulmonary fibrosis or not. Subjects and methods: This study included sixty seven Egyptian patients with diffuse parenchymal lung diseases (DPLD) recruited from the outpatient clinic and the chest department, Faculty of medicine, Cairo University and twenty healthy control subjects in the period between November 2015 and April 2017. The included subjects were divided into three groups: group I: 20 patients of idiopathic pulmonary fibrosis UIP/IPF recruited from the outpatient clinic and the chest department, Faculty of medicine, Cairo university confirmed by HRCT chest. group II: 47 patients of DPLD other than UIP/IPF recruited from the outpatient clinic and the chest department, Faculty of medicine, Cairo university confirmed by HRCT chest. group III: 20 normal healthy subjects as control group.