الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Background: Acanthosis nigricans (AN) is a skin disorder characterized by symmetrical, thickened, dark plaques comprising hyperkeratosis and acanthosis. Vitamin D (VD) plays an important role in regulation of skin proliferation and differentiation, and mediates its action by binding to specific vitamin D receptors (VDR) in the nuclei of target cells. Aim of the work: The aim of this study is to measure the serum levels of VD and tissue levels of VDR in a group of Egyptian patients with AN in comparison to healthy controls, in order to clarify the role of VD and VDR in AN which will help in the management protocol. Patient and Methods: This study included 25 AN patients and 25 age and sex matched healthy individuals serving as control group. Blood samples and skin biopsies were taken from all participants for evaluation of serum VD and tissue VDR levels. Results: Serum VD and tissue VDR were significantly lower in patients than controls (p=0.000 for both). Patients had a more deficient pattern of VD status than controls (p=0.000). There was a statistically significant positive correlation between serum VD and tissue VDR in patients group (r= 0.632, p=0.001) as well as between age and serum VD in controls group (r=0.507, p=0.01). Conclusion: The present study suggests a possible role for low serum VD and tissue VDR levels in causing AN in genetically predisposed individuals, both through a direct effect on the skin or indirectly via its relation to the metabolic syndrome