الفهرس 
Spleen longitudinal diameter and IL-10 in patients with fatty liver and metabolic syndrome
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Abstract
Background: The prevalence of NAFLD has grown to epidemic proportions; it is currently the most common cause of abnormal liver biochemistry. Adipose tissue produces a large number of inflammatory molecules responsible for low-grade chronic inflammation and insulin resistance (IR). Obesity can be associated with systemic low-grade inflammation that contributes to obesity-related metabolic disorders. Spleen-derived IL-10 plays an important role in the prevention of hypothalamic inflammation and may be a therapeutic target for the treatment of obesity and hypothalamic inflammation. In addition, spleen enlargement was reported in patients with non-alcoholic fatty liver in recent studdies. Objectives: To evaluate longitudinal spleen diameter in a population with metabolic syndrome and fatty liver and its relation to IL-10 level, CRP, specific anthropometric, ultrasonographic and laboratory parameters Methods: A randomized case control study 60 patients with metabolic syndrome based upon the American Heart association 2004 guidelines for diagnosis of metabolic syndrome and have fatty liver diagnosed by ultrasound and 25 of age, sex matched healthy subjects. All patients were recruited from internal medicine department, internal medicine outpatient clinic and diabetes outpatient clinic, Kasr Elaini university hospital