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العنوان
Analytical study of some pharmaceutical nitrogenated cyclic compounds /
الناشر
Fatma Ahmed Shalaby ,
المؤلف
Fatma Ahmed Shalaby
هيئة الاعداد
باحث / Analytical Chemistry
مشرف / Laila Elsayed Abdelfatah
مشرف / Lories Ibrahim Bebawy
مشرف / Ali Mohamed Yehia
تاريخ النشر
2017
عدد الصفحات
125 P. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Analytical Chemistry
تاريخ الإجازة
9/8/2018
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

This work is concerned with stability indicating methods for determination of some drugs containing cyclic nitrogen including; zafirlukast (ZAF), aprepitant (APR). In this thesis different analytical techniques were adopted, namely, TLC-densitometric, spectrophotometric, spectrofluorimetric, chemometric, liquid chromatography, for the determination of the previously mentioned compounds in their pure powder, laboratory prepared mixtures and dosage forms. In part I; general introduction and literature review of ZAF and APR were described. In part II; different analytical methods were described for the determination of ZAF in presence of its alkaline degradates. Including; TLC-densitometry, second derivative (D2) spectrophotometry, specerofluorimetry, colorimetry. In part III; different analytical methods were described for the determination of APR in presence of its acid degradates. Including; TLC-densitometry, HPLC method, chemometry