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العنوان
Expression of Micro RNAs 206 and 133b and serum IL-17 levels in preeclamptic females /
الناشر
Ayman Mohammed Hany ,
المؤلف
Ayman Mohammed Hany
هيئة الاعداد
باحث / Ayman Mohammed Hany
مشرف / Yasser Hussein Nassar
مشرف / Mostafa Mohammed Mostafa
مشرف / Salah Aly Sanad ,
تاريخ النشر
2017
عدد الصفحات
156 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء الحيوية (الطبية)
تاريخ الإجازة
10/9/2018
مكان الإجازة
جامعة القاهرة - كلية الطب - Medical Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 185

from 185

Abstract

The human placenta is a rapidly evolving organ that harbors a rich and diverse transcriptome. It is estimated that 66% of all human proteins are expressed in the placenta (Uhlen et al., 2016). Not surprisingly, the human placenta also expresses numerous types of miRNA species, with a fraction of these species being specific to trophoblasts (Luo et al., 2009).MicroRNAs (miRNAs) are small noncoding RNAs that act at a posttranscriptional level to degrade target genes recognized by complementary base pairing in the 3{u2019}untranslated region of the mRNA.Through inhibition of protein translation or promotion of mRNA degradation, miRNAs have roles in physiological and pathological processes such as cell differentiation, proliferation/growth, apoptosis, angiogenesis, inflammation, redox signaling and other endothelial cell functions (Zhang 2008). Since these processes are disrupted in preeclampsia,miRNAs can potentially play significant roles in preeclampsia pathogenesis. miRNAs may provide a novel strategy for better understanding of preeclampsia and its diagnosis