الفهرس 
Interleukin-10 gene polymorphism in Egyptian breast cancer patients
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Abstract
Breast cancer isthe main cause of death in women worldwide. Indeed, genetic variation plays a vital role in carcinogenesis. Inflammatory breast cancer (IBC) is an aggressive and fatal form of breast cancer that is more prominent among young women and is characterized by a high number of axillary lymph node metastases at the time of presentation, poor prognosis and low survival rate(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014). Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, -1082A/G, -819T/C and -592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. As we targeted the most commonly three studied IL-10 promoter SNPs; rs1800896 ({u2212}1082A/G), rs1800871 ({u2212}819T/ C) and rs1800872 ({u2212}592A/C), GCC haplotype was found in association with over-increase in the risk of IBC. Also we found no association of IL-10 gene promoter polymorphisms in breast cancer progression (Stage, Grade, lymph node metastasis and distant metastasis). Moreover, we found increased expression of IL-10 gene in non-IBC and IBC than healthy control samples but a higher significant expression of IL-10 mRNA in IBC carcinoma tissues compared to non-IBC. GCC haplotype was the most correlated with increased expression of IL-10 than other estimated haplotype, and a markedly significant increase in IL-10 expression of GCC haplotype in IBC than non-IBC carcinoma tissue