الفهرس 
The role of interim 18F-FDG PET CT in prediction of response in patients with diffuse large B cell lymphoma
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Abstract
Purpose: Evaluation of the role of interim FDG-PET/CT in prediction of response in patients with DLBCL. Patients & Methods:thirty nine patients with newly diagnosed pathologically proven DLBCL underwent baseline F-18-FDG PET-CT, interim PET-CT done after the 3rd cycle .At the end of treatment (6 cycles of chemotherapy+/- radiotherapy), F-18-FDG PET-CT will be conducted again and to be compared by interim F-18-FDG PET-CT results. F-18-FDG PET-CT results were interpreted using visual (Deauville) and quantitative analysis in the term of SUV max and TLG. Using pathological data and / or combined clinical / radiological data for follow up. Sensitivity, specificity, PPV, NPV and overall accuracy were estimated for interim F-18-FDG PET-CT results. End F-18-FDG PET-CT results were interpreted using Deauville, RECIST and ECRTEC criteria. Results: Interim F-18-FDG PET-CT was a significant prognostic factor of response at the end of treatment (P value=0.002) by using the Deauville criteria.ROC analysis of the interim results by the quantitative approach using the {u2206}SUVmax between baseline and interim PET-CT was also statistically significant (P value = 0.05),with 74.3% sensitivity, 75% specificity,74.3% accuracy, negative predictive value of 96.3% and lower positive predictive value of 25% Conclusion:interim F-18-FDG PET-CT can be a guide for risk-adapted strategy in DLBCL patients