الفهرس 
Clinical and ultrasonographic evaluation of intra-articular injection of platelet-rich plasma in Egyptian patients with primary knee osteoarthritis
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Abstract
Purpose: The aim of the current study was to determine the effectiveness of intraarticular injection of platelet rich plasma (PRP) in patients with primary knee osteoarthritis (OA) by clinical evaluation and ultrasonographic assessment of cartilage thickness. Patients And Methods: 100 patients were taken with mild to severe primary knee OA were divided into 2 groups: group I: 50 patients who were subjected to intra-articular knee injection of (PRP) twice 1 week apart and group II: 50 patients who were kept on non-steroidal anti-inflammatory drugs (NSAID) and chondroprotective drugs, as the control group. Functional assessment of all OA patients was done using WOMAC score basally, at 2nd and 6th months.Ultrasonographic assessment of femoral condylar cartilage thickness is done basally and at 6th months. Results:A significant improvement of WOMAC has occured at 2nd month and 6th month in group I following PRP injection compared to group II (p values < 0.001). There has been improvement at 6th month versus 2nd month in group I only (p values<0.001), while a significant worsening of WOMAC started to occur at 6th month relative to 2nd month in group II (p values <0.001 and t-value = -15.6). There was a significant improvement in WOMAC in group I as regards all severity degrees of OA than group II (p<0.001). There was no significant correlation between age and WOMAC among patients of group I at 2nd and 6th months follow up (p=0.066 and 0.682 respectively).There was a significant increase in cartilage thickness at the intercondylar area (ICA) at 6th month relative to baseline assessment by ultrasonography in group I (p=0.041). Conclusion: Treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of life in patients with various degrees of articular degeneration