الفهرس 
Antiviral evaluation of secondary metabolites derived from actinomycetes conjugated to silver nanoparticles
ContentsOnly 14 pages are availabe for public view
 |  | from | 188 |  |  |
| | | from | 188 | | |
Abstract
Virus infections pose significant global health challenges, due to the emergence of resistant viruses. Therefore, it is imperative that safe and conventional antiviral drugs be developed. In the present study, Actinomycetes isolated form Egyptian soil samples were used to investigate the possibility of acquiring antiviral activity from their metabolites by testing against three selected virus models. Results revealed that the sixth fraction purified from isolate (HA1) metabolites induced significant reduction of virus infectivity titer recording 62%, 46.5% and 44.1% log reduction in virus infectivity for HAV, HSV-2 and VSV respectively and the isolate was identified as Streptomyces avermitilis as blasted on the NCBI database. Further evaluation of the antiviral activity of the metabolite against the three virus models was attempted by conjugation to silver nanoparticles