الفهرس 
The association between DRD2/ANKK1 TaqIA Polymorphism and impulsivity in patients with opioid dependence disorder
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Abstract
Background : Drug addiction is a multifactorial disorder. Researchers have posited that an individual{u2019}s inherited behavioral propensity or temperament contributes to the disorder by shaping a personality strongly linked with the risk of drug abuse. Further, they hypothesize that the polymorphism of dopamine D2 receptor increases the susceptibility to and severity of addiction. We, therefore, investigated possible associations between dopamine D2 receptor (DRD2) and personality traits among patients with opioid dependence. Methodology: we assessed 80 patient with opioid dependence disorder using Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) to confirm the diagnosis of SUD. Impulsivity levels was measured by UPPS impulsivity scale and the severity of SUD was measured by the addiction severity index. We extracted DNA from the subjects{u2019} whole blood and genotyped it for TaqIA polymorphism. Results: Genotype analysis showed that 33.8 % of the subjects had TaqIA polymorphism vs. 66.3 % had normal genotype. The mean value of Urgency subscale of the UPPS in patients with normal genotype is (35.8 ± 9.0) vs. (40 ± 8.4) in patients with polymorphism. Conclusion: Patients with TaqIA polymorphism shows statistically significant higher levels of urgency on UPPS than patients with wild genotype. Patients with TaqIA polymorphism have significantly higher levels of impairment in legal status and family and social relations subscales of addiction severity index