الفهرس 
Association of CD40 Gene polymorphism and immune thrombocytopenic purpura (ITP) in adolescent and adult Egyptian population
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Abstract
Background: Adult immune thrombocytopenic purpura (ITP) is a chronic acquired organ-specific autoimmune disorder characterized by accelerated platelet destruction. This is due to the production of autoantibodies against platelets which results in the destruction of platelets via the reticuloendothelial system (RES). Aim: The current case-control study aimed at detecting rs4810485 and rs1883832 polymorphisms of CD40 gene in adolescents and adult Egyptians with persistent/chronic ITP to clarify their possible association with chronic evolution of the disease. Subjects and Methods: The current study included 50 persistent/chronic ITP patients and 50 matched unrelated healthy controls. Genotyping was performed by using polymerase chain reaction restriction fragment length polymorphism technique (PCR-RFLP). Results: rs1883832 genotyping revealed that the frequency of the wild C/C, heterozygous C/T, homozygous T/T genotypes, T allele and C allele among ITP patients were 8%, 48% , 44%, 68% and 32% respectively versus 4%, 56%, 40%, 68 % and 32% in the control group, while rs4810485 genotyping revealed that the frequency of the wild G/G, heterozygous G/T, homozygous T/T genotypes, T allele and C allele among ITP patients were 8%, 48% , 44%, 68% and 32% respectively versus 8%, 32%, 60%, 76 % and 24% in the control group, with no statistically significant difference between the two groups. It was found that combined genes polymorphism genotyping has strong statistically significant difference between the two groups p<0.01. Conclusion: The present results indicate a strong association between combined polymorphism of both genes and the susceptibility of developing chronicity of ITP in adolescent and adult Egyptian population