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Abstract The high voltage applications cooling uses the double distilled water (DDW) as a cooling fluid because of its low electrical conductivity. This study was performed for enhancing the cooling of the MGC-20 cyclotron by using the metal oxides nanofluids as a cooling fluid. The aluminum oxide (Al2O3), copper oxide (CuO) and magnesium oxide (MgO) were used as metal oxides nanoparticles for nanofluids synthesizing to examine the availability of using them as cooling fluids in the MGC-20 cyclotron. The Al₂O₃, CuO and MgO nanofluids were prepared with different weight concentrations of nanoparticles oxides. The thermal conductivity (TC) of Al₂O₃, CuO and MgO nanofluids were increased with temperature rising as well as with increase of the oxides concentration in the nanofluid, where the1.2% wt. CuO nanofluid offered about 16 % increase than the DDW TC at room temperature (RT), then the 1.2% wt. Al₂O₃ nanofluid thermal conductivity increased by 7% and the 1.2% wt. MgO nanofluid increased by 3% at RT. The electrical conductivity was measured for the all nanofluids and it increased with increase of the oxides concentration, as well as with temperature increase. the 1.2% Al₂O₃ nanofluid was the most suitable nanofluid for the high voltage applications and it was tested in a heat transfer system. the overall heat transfer coefficients of the 1.2% Al₂O₃ nanofluid were greater than the double distilled water coefficients at the different flow rates (by about 13%:17%). So the 1.2% wt. of Al₂O₃ nanofluid could be used for enhancing the cooling process in the high voltage applications especially for the MGC-20 cyclotron |