الفهرس 
INTRODUCTION AND LITERATURE REVIEWOnly 14 pages are availabe for public view
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Abstract
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection and generalized inflammation, which eventually precipitates serious cardiovascular complications, and end organ dysfunction (Singer et al., 2016). There has been an ongoing progress in the definition and management of sepsis over the last three decades, possibly due to the advances made in the understanding of the pathophysiology of sepsis. Conventionally, sepsis was perceived as an excessive systemic pro-inflammatory reaction to invasive microbial pathogens (Schulte et al., 2013). Recently, sepsis manifestations are no longer attributed to the infectious agent and the immune response it elicits, but also to substantial alterations in coagulation, immunosuppression, and organ dysfunction it causes (Gyawali et al., 2019).