الفهرس 
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Abstract
Summary
We are currently at the dawn of a revolution in the field of fatty liver diseases. Recently, a consensus recommended “metabolic (dysfunction) associated fatty liver disease” (MAFLD) as a more appropriate name to describe fatty liver disease associated with metabolic dysfunction. MAFLD is a multisystem disease associated with a plethora of hepatic and extrahepatic manifestations and comorbidities.
One thousand and five hundreds subjects were enrolled in our study. They were recruited from Beni-Suef Universityin the duration from February 2021 to June 2022.
The aim of the study was screening of metabolic associated fatty liver disease (MAFLD) and advanced liver fibrosis and increasing awareness of MAFLD risks.
The results of the study showed that:
1- The mean age of the studied patients was (49.5±12.6) years.
2- The prevalence of MAFLD was 56.4% in the studied patients.96.8% of MAFLD group were obese persons, 3.1% were lean persons.
3- There was a significant association between MAFLD and older age, female sex, higher BMI ≥25 and higher waist circumference.
4- There was a significant association between MAFLD and diabetes mellitus and hypertension.
5- There was a significant association between MAFLD and lower hemoglobin, higher platelets, higher creatinine, higher cholesterol, HBA1c, HOMA-IR, higher TG and VLDL.
6- There was a significant association between MAFLD and higher E/e`, LA diameter, diastolic dysfunction grade II.
7- There was a significant association between MAFLD and higher liver stiffness, higher degree of fibrosis by TE-KPA and higher stages of steatosis. F 2 was significantly higher in MAFLD. Stage 3 of steatosis was higher in MAFLD group.
8- There was a significant positive linear correlation between the Elastography with Waist circumference, SBP, DPB, TLC, TE-KPA, and global longitudinal strain.
9- Older age, female sex, DM, HTN, high HOMA-IR, high total cholesterol, high platelets, high APRI and high CAP were the independent risk factors that increase the probability of MAFLD among the screened subjects.
10- Compared to non MAFLD subjects, the lean MAFLD patients were older in age with higher prevalence of thyroid disease, hypertension and diabetes.
11- There was a significant increase in physical activity, prevalence of thyroid disease and HBV, but decrease in stage of fibrosis in lean MAFLD group compared to obese MAFLD group.