الفهرس 
Gout
Hyperuricemia and CKDOnly 14 pages are availabe for public view
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Abstract
Gout is a metabolic disorder characterized by disturbance in purine metabolism and urate excretion with manifestations of acute and chronic arthritis and tophus formation. Impaired kidney function is among the important risk factor for gout. Musculoskeletal ultrasound can detect crystals deposition in soft tissue and joints early in the course of the disease. Aim of work To evaluate the role of musculoskeletal ultrasound (MSUS) in early detection of gout in CKD patients. Subject and methods This study was carried out on 50 patients with CKD according to K/DOQI classification of CKD. Musculoskeletal ultrasound assessment for wrist, hand, foot and knee joints was done for all patients then they were divided into 2 groups according to presence or absence of MSUS specific findings of gout as double contour sign (DCS) and/or tophus formation. Statistical analysis carried out for all collected data using SPSS statistical significance was determined at as P value < 0.05. Results Using MSUS revealed that 35 patients (70%) had positive ultrasound findings for gouty arthritis. 10 of this group (28.6 %) were non hyperuricemic. The group of patients with positive sonographic findings had significant higher serum uric acid and older age than other group (P value =0.004), (P value < 0.001) respectively. MSUS reveled sensitivity 95 % and specificity 95 % in the detection of gout in patient with CKD. Conclusion MSUS is considered a reliable tool with high sensitivity and specificity in screening of gouty arthritis in asymptomatic hyperuricemic patients.