الفهرس 
DEPRESSION IN HEMODIALYSIS PATIENTSOnly 14 pages are availabe for public view
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Abstract
Background: Depression is associated with morbidity, death, diminished quality of life, decreased longevity, and even suicidal ideation in dialysis patients. Intra-dialytic exercise improves hemodialysis effectiveness, reducing inflammation, increasing exercise tolerance, and decreasing depression.
Results: This prospective cohort research comprised 50 hemodialysis patients with depressive symptoms separated into two groups: group I underwent intra-dialytic exercise for three months and group II was matched in age and gender but did not undertake any exercise. Hamilton depression rating scale was significantly decreased in group I after completing the exercise program more than group II (p=0.000). Serum tumor necrosis factor alpha significantly decreased in group I compared to baseline (P=0.000), while there was no change in group II. A positive correlation was found between serum tumor necrosis factor alpha and Hamilton depression rating scale (r =0.676), (P=0.000). Physical activity tests; six-minute walk test, rapid assessment of physical activity and peak volume of oxygen consumption were significantly improved in group I compared to baseline (P=0.000), while there was no statistically significant difference in group II.
Conclusions: Intra-dialysis exercise can improve depression and physical performance in hemodialysis patients. Because a decrease in blood tumor necrosis factor alpha after completing an intra-dialytic exercise program was related with depression improvement, so tumor necrosis factor alpha may be an essential inflammatory marker of depression in hemodialysis patients.