الفهرس 
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Abstract
Summary Schistosomes are blood-dwelling flukes which are highly dependent on the host metabolism. Several host–derived factors, such as insulin, glucose and tumour necrosis factor (TNF) have been described to influence worm growth and egg deposition. Any change of the normal host metabolism could disrupt oviposition or worm development. About 422 million people worldwide have diabetes, the majority living in low- and middle-income countries, with 1.5 million deaths each year. 13% of adults in the world are obese. Over 340 million children and adolescents were overweight or obese in 2016. Therefore, the aim of the present work was to study the interaction between Schistosoma mansoni infection and the metabolic disorders diabetes mellitus types 1 and 2 (DM1, DM2), and obesity. We report on parasitological, histopathological, biochemical, and immunological parameters in a mouse model of hepatic schistosomiasis to identify the underlying possible mechanisms of these co-morbidities. In order to fulfill this aim, the following was done: The study animals were divided into four groups. group I represented the control groups, including normal, S. mansoni infected, and non-infected DM1, DM2, and obese groups. The mice of the other three groups undergone induction of DM1 (group II), DM2 (group III) and obesity (group IV) before being infected by S. mansoni. ll mice groups were subjected to the following: Total body weight, food, energy intake Total body weight and fasting blood glucose level were measured weekly, food intake was monitored daily.