الفهرس 
Study of the association of protein tyrosine phosphatase non receptor type 22 (PTPN22) C1858T gene polymorphism with type 1 diabetes mellitus
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Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune multifactorial disease. The protein tyrosine phosphatase non receptor 22 gene (PTPN22) is an important inhibitor of T{u2010}cell receptors activation (TCR). A single{u2010}nucleotide polymorphism (SNP) C1858T within this gene was shown to be a risk factor for several autoimmune diseases. The aim of this study was the investigation of possible association between C1858T SNP of protein tyrosine phosphatase non receptor type 22 (PTPN22) and T1DM. The current study evaluated the PTPN22 C1858T polymorphism in 45 previously diagnosed T1DM subjects and 43 healthy age and sex matched subjects with no family history of T1DM or any other types of autoimmune disease. Genotyping was performed by real time PCR. Statistical comparisons for the distribution of genotypes and allele frequency for the PTPN22 C1858T polymorphism between T1DM patients and controls showed no statistically significant difference. There was a statistically non-significant association between the PTPN22 genotypes and gender and age at onset of T1DM among the patients’ group . No statistically significant association was found between the PTPN22 C1858T polymorphism and T1DM