الفهرس 
Diagnostic accuracy of whole-body diffusion imaging with background signal suppression (DWIBS) for evaluation of breast cancer patients; a comparison with PET/CT
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Abstract
Purpose: We performed a comparison between the diagnostic value of F-18-FDG PET-CT and WB-MRI/DWIBS for in assessment of breast cancer patients.Patients & Methods: fifty patients with pathologically proven breast cancer underwent both F-18-FDG PET-CT and WB-MRI/DWIBS. The sequences acquired are whole body DWI, coronal T1 and coronal STIR. FDG-PET/CT was performed on an integrated PET-CT system. Whole body F18 FDG-PET CT was performed using standard technique. Both F-18-FDG PET-CT and WB-MRI/DWIBS were independently interpreted using visual qualitative and quantitative analysis in the term of SUV max and ADC value respectively. Using pathological data and / or combined clinical / radiological follow up as a reference standard, Sensitivity, specificity, PPV, NPV and overall accuracy were estimated for both techniques.Results: F-18 FDG PET-CT demonstrated slightly higher specificity indices than MR-DWIBS while the MR-DWIBS displays higher sensitivity indices than FDG PET CT in particular in loco-regional assessment. In addition, high sensitivity indices of DWIBS were depicted in assessment of nodal and bone marrow lesions with fair specificity indices. A high degree of agreement also existed between DWIBS and PET CT with little better accuracy of FDG PET CT more appreciated in the pulmonary lesions assessment.Conclusion: WB-MRI/DWIBS is a promising tool in evaluation of breast cancer patients. Further improvement should be done for DWIBS to have alternative role to FDG PET CT